FabGennix/PREX1 Antibody/PREX-101AP/
Product | PREX1 Antibody |
Description | Affinity Purified Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody |
Verified Applications | ELISA, IHC, IP, WB |
Host | Rabbit |
Species Cross Reactivity | Human, Monkey, Mouse, Rat |
Immunogen | Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.6 µg/µl in antibody stabilization buffer |
Form | Affinity Purified |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
DB | 1:20,000-1:50,000 |
ELISA | 1:20,000-1:50,000 |
| Immunohistochemistry | 1:50-1:150 |
| Immunoprecipitation | 1:500 |
Western Blot | 1:500-1:750 |
Protein | |
Uniprot # | Q8TCU6 |
Overview | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
Molecular Function | enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding |
Subcellular Location | Cytoplasm, cell membrane |
Expression | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
Alternative Nomenclature | 4 antibody 5)-dependent Rac exchanger 1 antibody P REX1 antibody PtdIns(3,4,5) dependent Rac exchanger 1 antibody SET domain containing 6 antibody Setd6 antibody |
Protein information supplied by UniProt
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