MedKoo Biosciences/ARQ-501 (beta lapachone)/200284/50mg
MedKoo Cat#: 200284 Name: ARQ-501 (beta lapachone) CAS#: 4707-32-8 Chemical Formula: C15H14O3 Exact Mass: 242.09429 Molecular Weight: 242.27 Elemental Analysis: C, 74.36; H, 5.82; O, 19.81
Synonym: ARQ501 beta lapachone; 34Dihydro22dimethyl2Hnaphtho(12b)pyran56dione.
IUPAC/Chemical Name: 2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione
InChi Key: QZPQTZZNNJUOLS-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h4-6H,7-8H2,1-2H3
SMILES Code: O=C1C(CCC(C)(C)O2)=C2C3=CC=CC=C3C1=O
Technical Data
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Harmonized System Code: 293490
Additional Information
References
1: Kim JH, Lee SM, Myung CH, Lee KR, Hyun SM, Lee JE, Park YS, Jeon SR, Park JI, Chang SE, Hwang JS. Melanogenesis inhibition of β-lapachone, a natural product from Tabebuia avellanedae, with effective in vivo lightening potency. Arch Dermatol Res. 2015 Feb 8. [Epub ahead of print] PubMed PMID: 25663088.
2: Moore Z, Chakrabarti G, Luo X, Ali A, Hu Z, Fattah FJ, Vemireddy R, DeBerardinis RJ, Brekken RA, Boothman DA. NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone. Cell Death Dis. 2015 Jan 15;6:e1599. doi: 10.1038/cddis.2014.564. PubMed PMID: 25590809.
3: Menacho-Márquez M, RodrÃguez-Hernández CJ, Villaronga MÃ
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