ProductDescription
LY2228820isapotentandselectiveATP-competitiveinhibitoroftheα-andβ-isoformsofp38mitogen-activatedproteinkinases(MAPKs).Itinhibitsp38αandp38βwithIC50valuesof5.3nMand3.2nM,respectively.[1]Incell-basedassays,LY2228820selectivelyinhibitedthelevelofphospho-MAPKAP-K2(pMK2)inanisomycin-inducedRAW264.7cells,withIC50of35.3nM.LY2228820alsoinhibitslipopolysaccharide(LPS)/IFN-γ-inducedTNFαformationinmurineperitonealmacrophages,withIC50of6.3nM.[1]FurThermore,LY2228820inhibitsangiogenicendothelialcordformationinmultipleinvitroandinvivoassaymodels.[2]
LY2228820iscurrentlybeingevaluatedinPhaseI/IIclinicaltrialsinpatientswithnewlydiagnosedglioblastoma[3]andplatinum-sensitiveovariancancer[4]."
Technicalinformation:
ChemicalFormula: | C24H29FN6.2CH4O3S | |
CAS#: | 862507-23-1 | |
MolecularWeight: | 612.74 | |
Purity: | >98% | |
Appearance: | Off-white | |
ChemicalName: | 5-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-aminedimethanesulfonate | |
Solubility: | Upto100mMinDMSO | |
Synonyms: | LY-2228820,LY2228820,LY2228820dimesylate, |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderorDMSOsolutionat-20oCdesiccated.
Reference:
1. | CampbellRM,etal.CharacterizationofLY2228820dimesylate,apotentandselectiveinhibitorofp38MAPKwithantitumoractivity.MolCancerTher.2014;13(2):364-74PubmedID:24356814 |
2. | TateCM,etal.LY2228820dimesylate,aselectiveinhibitorofp38mitogen-activatedproteinkinase,reducesangiogenicendothelialcordformationinvitroandinvivo.JBiolChem.2013;288(9):6743-53PubmedID:23335506 |
3. | StudyofLY2228820WithRADIotherapyPlusConcomitantTMZintheTreatmentofNewlyDiagnosedGlioblastoma(GLYRad).clinicaltrials.gov/NCT02364206 |
4. | AStudyofLY2228820forRecurrentOvarianCancer. clinicaltrials.gov/NCT01663857 |
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急求日本《医药品添加物事项》中有关“十六醇”的资料,请各位大神帮帮忙
不过因为食品添加剂种类很多,适应范畴和添加量都是规定的,如果你未按gb2760的规定使用,可能构成违法,具体是否是犯罪,要看具体的性质。
比如:二氧化钛(就是食品级的钛白粉)允许在允许在膨化食品、果冷、凉果等类限量使用,如果你在肉制品中使用,属于超范围墙使用,就是违法行为。
其次是超量使用,一般超量使用,又没有构成严重后果,属滥用食品添加剂,一般不按犯罪处理。
但超范围使用,加上媒体炒作的话,可能就麻烦了,因为公-安-执-法部门对此不太专业,往往会有意无意的扩大化,有可能会按刑法143条,生产销售伪劣食品罪起诉。
要注意:食品添加剂和非法添加物的区别,食品添加剂是国家允许使用的物质,而非法添加剂则是指食品及添加剂以外的物质,如三聚氰胺、吊白块、苏丹红等,不是食品添加剂,如果使用此类物质,则构成犯罪。
相容性药品包装材料与药物相容性试验指导原则2.pdf(43.35k)
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