Description
TelbivudineisanantiviralandimmunomodulatorycompoundthatiscommonlyusedtotreatchronichepatitisBinfections.TelbivudineistheL-isomerofthymidineandactsasanucleosideanalog.Clinically,telbivudineincreasesexpressionofCD127onCD8+memoryTcells;thiscompoundalsodecreaseshepatitisBviralDNAandnormalizeslevelsofalanineaminotransferase.
References
NanXP,ZhangY,YuHT,etal.InhibitionofviralreplicationdownregulatesCD4(+)CD25(high)regulatoryTcellsandprogrammeddeath-ligand1inchronichepatitisB.ViralImmunol.2012Feb;25(1):21-8.PMID:22233255.
LvG,YingL,MaWJ,etal.DynamicanalysisofCD127expressiononmemoryCD8TcellsfrompatientswithchronichepatitisBduringtelbivudinetreatment.VirolJ.2010Aug31;7:207.PMID:20807412.
LaiCL,LeungN,TeoEK,etal.A1-yeartrialoftelbivudine,lamivudine,andthecombinationinpatientswithhepatitisBeantigen-positivechronichepatitisB.Gastroenterology.2005Aug;129(2):528-36.PMID:16083710.