Tocris产品目录价格 Tocris Bioscience抗体品牌,Tocris/Rifaximin/5359/50/50 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/Rifaximin/5359/50/50 mg

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Tocris

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5359/50

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4000-520-616

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Description:PregnaneXreceptoragoNIST;antibiotic

ChemicalName:(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PregnaneXreceptor(PXR)agonist;antibiotic.ReducesnumberofcolontumorsandsuppressesexpressionofTNFαandIl-1βinducedinacoloncancer,PXR-humanizedmousemodel.IncreasesapoptosisanddecreasedproliferationinHT-29cells.Exhibitslowgastrointestinalabsorptionwhileretainingitsantibacterialactivity.Activeagainstgram-positiveandgram-negativebacteria.

TechnicalData

M.Wt	785.88
Formula	C₄₃H₅₁N₃O₁₁
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	80621-81-4
PubChemID	6436173
InChIKey	NZCRJKRKKOLAOJ-XRCRFVBUSA-N
Smiles	O=C(/C(C)=CC=C[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	78.59	100
	ethanol	78.59	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight785.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.27mL	6.36mL	12.72mL
5mM	0.25mL	1.27mL	2.54mL
10mM	0.13mL	0.64mL	1.27mL
50mM	0.03mL	0.13mL	0.25mL

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BiologicalActivity

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