BiologicalActivity
GABAuptakeinhibitor(IC50=67nMinvivo).ExhibitshighaffinityandselectivityfortheGAT-1GABAtransporter.Anticonvulsant;alsoattenuatesestablisheddynorphin-inducedallodyniainamousemodelaftersystemicadmiNISTration.
CompoundLibraries
TiagABInehydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 412.01 |
| Formula | C20H25NO2S2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 145821-59-6 |
| PubChemID | 91274 |
| InChIKey | YUKARLAABCGMCN-PKLMIRHRSA-N |
| Smiles | CC3=C(SC=C3)/C(C2=C(C)C=CS2)=CCCN1C[C@H](C(O)=O)CCC1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.2 | 100 | |
| water | 20.6 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight412.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.43mL | 12.14mL | 24.27mL |
| 5mM | 0.49mL | 2.43mL | 4.85mL |
| 10mM | 0.24mL | 1.21mL | 2.43mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
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