BiologicalActivity
p53stabilizingagent.Stabilizestheactiveconformationofp53andpromotesp53activityincancercelllineswithmutantorwild-typep53.Inhibitsgrowthofsmallhumantumorxenograftsinvivo.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 435.39 |
| Formula | C22H26N4O.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1217195-61-3 |
| PubChemID | 56972205 |
| InChIKey | WWIFDJIOGCGSBS-IVKCLRODSA-N |
| Smiles | COC(C=C3)=CC=C3/C=C/C2=NC1=CC=CC=C1C(NCCCN(C)C)=N2.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.54 | 100 | |
| water | 43.54 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight435.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.3mL | 11.48mL | 22.97mL |
| 5mM | 0.46mL | 2.3mL | 4.59mL |
| 10mM | 0.23mL | 1.15mL | 2.3mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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