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Description:Selective,non-competitiveAMPAantagoNIST
ChemicalName:3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selective,non-competitiveAMPAantagonist(IC50=25nMinratcorticalneurons)thatdisplayspotentanticonvulsantactivity.AlsosignificantlyblocksthepersistentcomponentofNav1.6channelactivity.Brainpenetrantandorallyactive.
TechnicalData
M.Wt | 499.41 |
Formula | C26H24ClFN4O.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 199655-36-2 |
PubChemID | 53251536 |
InChIKey | YKYDGCRJPYLXHY-GVYCEHEKSA-N |
Smiles | O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.94 | 100 | |
water | 4.99 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight499.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2mL | 10.01mL | 20.02mL |
5mM | 0.4mL | 2mL | 4mL |
10mM | 0.2mL | 1mL | 2mL |
50mM | 0.04mL | 0.2mL | 0.4mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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