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Description:Broadspectrumcationchannelblocker;neuroprotective
ChemicalName:3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamidehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Broadspectrumcationchannelblocker.Inhibitsseveralcationchannelsincludingstore-operatedcalciumchannels(SOCs),voltage-operatedcalciumchannels(VOCs),non-selectivecationchannels(NSCCs),AMPA,NMDA,Na+andK+channels.Neuroprotective;reducescorticalinfarctsizeandimprovesneurologicaloutcomefollowingmiddlecerebralarteryocclusion.
TechnicalData
M.Wt | 749.29 |
Formula | C41H48N2O9.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 143482-60-4 |
PubChemID | 56846451 |
InChIKey | UDKSNBMNKLDHNK-UHFFFAOYSA-N |
Smiles | Cl.COC1=CC=C(CCN(CCC2=C(OC)C(OC)=C(OC)C=C2)C(=O)C(C2=CC=CC=C2)C2=NCCC3=CC(OC)=C(OC)C=C23)C(OC)=C1OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 74.93 | 100 | |
water | 37.46 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight749.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.33mL | 6.67mL | 13.35mL |
5mM | 0.27mL | 1.33mL | 2.67mL |
10mM | 0.13mL | 0.67mL | 1.33mL |
50mM | 0.03mL | 0.13mL | 0.27mL |
MolarityCalculator
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ReconstitutionCalculator
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DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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